Jones, P.D., & Giesy, J.P. (2017). Quantification of Dioxins by GC-Orbitrap MS.

Introduction: The need for stringently high chromatographic and mass spectrometric resolution has long been recognized for the analysis of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs). These requirements are due to the extremely small concentrations of PCDD/Fs found in the environment and the need to regulate these chemicals at pg/g concentrations. Technologies to provide the required sensitivity and specificity for PCDD/F analysis were developed in the mid to late 1980s with the development of analytical protocols based on magnetic sector instrumentation (USEPA 1997. Recent developments in high resolution Orbitrap technology make possible new levels of mass resolution and sensitivity suitable for identification and quantification of PCDD/Fs. This study compared results from Orbitrap GC/MS analysis of PCDD/Fs to data produced by using of a magnetic sector system and to the requirements of USEPA methods for the analysis of PCDD/Fs.

noproject,accepted